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Monday, May 11, 2020 | History

4 edition of Blood platelet function and medicinal chemistry found in the catalog.

Blood platelet function and medicinal chemistry

  • 367 Want to read
  • 26 Currently reading

Published by Elsevier Biomedical in New York .
Written in English

    Subjects:
  • Blood platelets.,
  • Blood platelet disorders.,
  • Pharmaceutical chemistry.,
  • Blood platelets -- Physiology.,
  • Chemistry, Pharmaceutical.

  • Edition Notes

    Includes bibliographical references and indexes.

    Statementedited by Andrew Lasslo.
    ContributionsLasslo, Andrew.
    Classifications
    LC ClassificationsQP97 .B54 1984
    The Physical Object
    Paginationxvi, 324 p. :
    Number of Pages324
    ID Numbers
    Open LibraryOL3171942M
    ISBN 100444007903
    LC Control Number83014146

    Thrombin and several clotting factors present in plasma and calcium ions are involved in the coagulation. Process of blood coagulation can be described as follows. Whenever there is an injury to a blood vessel, there is formation of rough surface. When blood platelets come . Ticagrelor (Brilinta; AstraZeneca) acts as an antagonist, binding reversibly, to the P2Y 12 receptor, a main constituent of the blood platelets (Figure 40).P2Y 12 protein belongs to the family of the G-protein-coupled purinergic receptors that bind to adenosine diphosphate (ADP) to initiate cell signaling, thereby controlling blood clotting. Ticagrelor was approved by the FDA in as a.

    Alkaloids 1 and 4 exhibited significant inhibition of collagen, arachidonic acid, and platelet activating factor-induced platelet aggregation, and alkaloid 3 also showed an inhibitory effect on. The Medicinal Chemistry Course • ADME (adsorption, distribution, metabolism and excretion) of drugs • drug-receptor interactions • development of drugs • screening techniques • combinatorial chemistry (D.O.) • classical medicinal chemistry, hit-to-lead development • fragment-based drug design • rational drug design / de-novo drug design • natural products.

    The platelet membrane glycoprotein IIb-IIIa complex. Blood 71(4), – (). • Interesting information about the role of glycoprotein IIb/IIIa in platelets ef, Medline, CAS, Google Scholar; Ginsberg MH, Du X, Plow EF. Inside-out integrin . Platelet aggregation assays were performed in sheep and human blood in duplicates. Sheep blood was used for the bulk screenings, where a large volume of blood was needed. Human blood from the authors SSF (female, 32) and IT (female, 37) was used for selected extracts to verify an inhibitory effect seen in sheep blood at first screening.


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Blood platelet function and medicinal chemistry Download PDF EPUB FB2

The chapters contain discussions of the role of platelets in cardiovascular disease, platelet ultrastructure, normal and abnormal platelet function, endothelial physiology, and interactions between platelets and artificial surfaces and between platelets and medicinal and chemical : Andrew I.

Schafer. Blood platelet function and medicinal chemistry. New York: Elsevier Biomedical, © (OCoLC) Online version: Blood platelet function and medicinal chemistry. New York: Elsevier Biomedical, © (OCoLC) Document Type: Book: All Authors /. Full text Full text is available as a scanned copy of the original print version.

Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by : J Stuart. Handbook of Platelet Physiology and Pharmacology Softcover reprint of the original 1st ed.

Edition The book is extremely informative in the mechanics and biochemistry of platelet form and function. It is a textbook written well enough to be read by a college sophomore. Read more. Helpful.5/5(1).

The interactions of blood elements with artificial materials (bags, tubes, artificial organs, etc.) require many disciplines for its understanding.

Thus the effort presented in this book is the culmination of a genuine discussion on the problems arising in blood banks, in hospitals, in biomaterials development, in experimental hemocompatibility testing when platelets interact with : Hardcover.

Blood Platelet Function and Medicinal Chemistry. Coronavirus: Find the latest articles and preprints Blood Platelet Function and Medicinal Chemistry. Stuart J. Journal of Clinical Pathology, 01 Dec37(12): DOI: /jcpb.

This book provides a comprehensive survey of the importance of blood platelets for coronary heart diseases. It gives both research workers and clinicians an insight into the function of thrombocytes and the significance of platelets in the clinical framework of coronary heart diseases in order to create an understanding of the differntiated use of antithrombocytic principles.

• To monitor therapy (blood thinners, diabetes) • To screen for toxins/drugs Reference Ranges Dr. Harry Eidenier, Jr., whose work is widely recognized and well respected in the area of balancing blood chemistry, stated to me “ Blood chemistry, irrespective of range used (optimal or reference), is simply a tool to be used with other.

(B) Distinct phases of platelet function in primary haemostasis: Initial platelet tethering and adhesion at a site of vascular damage, firm adhesion and shape change, activation, granule secretion.

Blood platelets play a crucial role in the primary hemostasis and vessel wall repair. However; platelet hyperactivation is implicated in the pathogenesis of cardiovascular diseases such as thrombosis, atherosclerosis and stroke.

In keeping with the rising incidence of atherothrombotic disease, reliable platelet function testing has become more important. In acute coronary syndromes (ACS), platelets often play a starring role in the pathogenesis of disease and are a critical target for pharmacotherapy (1,2).

Platelets - winner of a Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine.

Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases. Platelet glycoprotein (GP)Ib-IX-V and GPVI are unique platelet receptors that bind von Willebrand factor or collagen, respectively, and control the initial interaction of circulating platelets with the blood vessel wall in physiology (hemostasis) or pathology (heart attack or stroke).

Sorry, our data provider has not provided any external links therefore we are unable to provide a link to the full : J Stuart. Platelets are the smallest blood cells and important for hemostasis. Platelet concentrates (PC) are medicinal products transfused to prevent or treat bleeding.

Typically, platelets in PCs are assessed by in vitro tests for their function. However, in vivo testing of these platelets is highly desirable.

The platelet P2T receptor plays a major role in platelet aggregation, and its antagonists are predicted to have significant therapeutic potential as antithrombotic agents. We have explored analogues of adenosine triphosphate (ATP), which is a weak, nonselective but competitive P2T receptor antagonist.

Modification of the polyphosphate side chain to prevent breakdown to the agonist adenosine. BLOOD PLATELETS Blood platelets are anucleate cells that serve a critical function in hemostasis.

In human body about 1× platelets are formed every day as the result of complex processes of differentiation, maturation and fragmentation of megakaryocytes (Xu et al. Individual platelets vary in terms of volume, density and.

Blood - Blood - Platelets (thrombocytes): The blood platelets are the smallest cells of the blood, averaging about 2 to 4 μm in diameter. Although much more numerous (, toper cubic millimetre) than the white cells, they occupy a much smaller fraction of the volume of the blood because of their relatively minute size.

Like the red cells, they lack a nucleus and are incapable of. function to recruit other blood-borne cells. In rest-ing platelets, granules are situated close to the OCS membranes.

During activation, the granules fuse and exocytose into the OCS.3 Platelets have two major rec-ognized storage granules: α and dense granules. The most abundant are α granules (about 40 per platelet).

European Journal of Medicinal Chemistry,; French S.L, Paramitha A.C, Moon M.J, Dickins R.A, Hamilton J.R. Humanizing the protease-activated receptor (PAR) expression profile in mouse platelets by knocking Par1 into the Par3 locus reveals Par1 expression is not tolerated in mouse platelets.

In: Lasslo A (ed) Blood platelet function and medicinal chemistry. Elsevier Biomedical, New York, pp 61– Google Scholar Packham MA, Mustard JF () The role of platelets in the development and complications of atherosclerosis.Biochemistry of Platelets is a comprehensive review of the biochemistry of platelets, with emphasis on the molecular basis for the various biological processes in which they participate.

Topics range from stimulus-response coupling mechanisms to platelet contractile proteins, platelet membrane glycoproteins, and storage organelles in platelets.Platelets, Second Edition PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine.

Medical books Platelets, Second Edition. Medical books Platelets, Second Edition. New Hardcover. Download link for Platelets, Second Edition Alan D. Michelson.